MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide composed of 16 amino acids, encoded by the mitochondrial genome. It plays a crucial role in regulating metabolic homeostasis, cellular stress responses, and insulin sensitivity. Unlike nuclear-encoded hormones, MOTS-C acts both in the cytoplasm and nucleus, influencing gene expression related to metabolism.
Preclinical studies have shown that MOTS-C activates AMP-activated protein kinase (AMPK) and enhances glucose utilization, mitochondrial function, and lipid metabolism. In a key animal study published in Cell Metabolism (2015), MOTS-C administration improved insulin sensitivity, protected against diet-induced obesity, and extended lifespan in mice on a high-fat diet. Early human data are limited but promising. A 2020 pilot study in older adults, published in Aging Cell, found that MOTS-C levels naturally decline with age and that exogenous MOTS-C administration enhanced physical performance and metabolic resilience.
- Product Name: Mots-C
- Molecular Formula: C101H152N28O22S2
- Molecular Weight: 2174.6 g/mol
- CAS Number: 1627508-64-6
- Unit weight: 10mg
- Form: Lyophilised Solid
USAGE AND STORAGE
Mots-C is supplied as a lyophilised solid to ensure maximum stability and ease of use in research environments. For optimal results store out of direct sunlight between 2-8 C° both before and after reconstitution. When reconstituting we recommend XL Peptides approved Bacteriostatic mixing water. When reconstituting ensure the peptide and mixing solution are at room temperature to prevent temperature shock and aid proper dilution.
SYNTHESIS AND QUALITY ASSURANCE
This peptide is meticulously synthesised through a controlled process that ensures high purity, making it suitable for advanced scientific studies. Our commitment to excellence guarantees that each batch undergoes stringent quality control.
